Effects of Carnosine and L-histidine on Viability and Expression of Pyruvate Dehydrogenase Kinase 4 in Human Glioblastoma Cells
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Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation
Here we analyzed whether the anti-neoplastic effect of carnosine, which inhibits glycolytic ATP production, can be antagonized by ATP production via oxidative phosphorylation fueled by pyruvate. Therefore, glioblastoma cells were cultivated in medium supplemented with glucose, galactose or pyruvate and in the presence or absence of carnosine. CPI-613 was employed to inhibit the entry of pyruvat...
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